i-PRF yields nearly double the amount of platelets, when compared to PRP:
i-PRF = 85% increase of platelets
PRP = up to -57% less platelets (less than what you started with!!)
i-PRF utilises activated platelets.
Platelets are released slowly with i-PRF, leading to greater tissue rejuvenation and bio-compatibility.
Activated platelets release a plethora of growth factors that potentially promote or inhibit angiogenesis and influence the reactivity of tissue repair and are known to regulate cell migration, vascularisation, cell proliferation, and deposition of new extracellular matrix.
The anticoagulant used in PRP inhibits platelet activation.
A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.
Growth factors release rate into the target tissue is important for tissue receptors to respond over a prolonged period of time following treatment.
The use of growth factors and fibrin for regenerative purposes represents a new approach to aesthetic medicine.
The three-dimensional cross-linked matrix massively traps the platelets and controls their release of growth factors “very slowly and continuously over a time period of more than one week".
Fibrin is a unique biomaterial, a scaffold for tissue engineering. You only find fibrin in iPRF, not PRP.
Not only does the fibrin act as a temporary extracellular matrix, it also traps the platelets and allows the slow release of growth factors which means a more effective biomaterial for tissue regeneration.
When PRP is re-injected, there is no fibrin to anchor the platelets where you want them and you lose the majority.
Fibrin also binds to Hyaluronic Acid which stimulates human fibroblast proliferation.