google-site-verification: google1d3a1023e5548db9.html

Fibrin

Fibrinogen is produced by the liver and found in blood plasma and platelet alpha-granules, it's a glycoprotein complex that circulates in the blood of vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby promotes revascularization and wound healing.

 

Thrombin

Thrombin is a naturally occurring enzyme that converts fibrinogen into fibrin. It is the only factor capable of cleaving fibrinogen to create fibrin.

The Role of Fibrin in Autologous Therapy

The use of growth factors and fibrin for regenerative purposes represents a new approach to aesthetic medicine. The process of tissue regeneration includes a complex set of biological events controlled by the action and synergy of a cocktail of growth factors. The three agents involved in tissue regeneration: the cellular component, a combination of multiple biological mediators that include growth factors and cytokines and a fibrin matrix that provides tissue construction support and acts as a net to trap platelets and growth factors.

 

Fibrinogen is produced by the liver and found in blood plasma and platelet alpha-granules, it's a glycoprotein complex that circulates in the blood of vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby promotes revascularization and wound healing.

 

The three-dimensional cross-linked matrix massively traps the platelets and controls their release of growth factors “very slowly and continuously over a time period of more than one week”. Growth factors release rate into the target tissue is important for tissue receptors to respond over a prolonged period of time following treatment. Fibrin binds to Hyaluronic Acid which stimulates human fibroblast proliferation within a collagen matrix.

Injectable Platelet Rich Fibrin (i-PRF) is liquid form, the fibrin network generated here leads to a more efficient cell migration and proliferation, unlike other platelet concentrates (PRP), i-PRF allows the platelets, growth factors and cytokines to be released slowly, thus offering a more effective biomaterial for tissue regeneration, wound healing and cell communication.

E: info@cosmopro.co.uk

W: www.iprfsmartcell.com

T: 0161 885 3191 

© 2019 by i-PRF Smart Cell. All rights reserved. Part of the Cosmo Pro Ltd Group