Growth factors are important for regulating a variety of cellular processes. Growth factors typically act as signalling molecule between cells.
Platelets release 7 fundamental growth factors:
Platelets only release growth factors once activated. i-PRF is a second generation platelet concentrate which is an improvement over traditionally prepared PRP, the mechanism of i-PRF yields a higher platelet count and thus a higher concentration of growth factors.
One of the drawbacks of PRP is the use of anticoagulant which inhibits the activation of platelets, once the PRP is injected it has limited ability to stimulate tissue regeneration as it then releases growth factors quickly.
i-PRF offers a favourable environment for growth factors as they get trapped in the fibrin mesh and released slowly over several days, allowing the tissue to regenerate and improve wound healing.
Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. PDGF is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells.
PDGF have antimicrobial properties which is often overlooked in autologous cell therapy. Antimicrobial peptides, both of which are induced during tissue remodelling and repair.