The Smart Cell i-PRF system is scientifically proven to contain more platelets per mcL than traditional PRP.
i-PRF increases the remodelling of tissue through stimulating the removal of photo-damaged ECM components and inducing synthesis of new collagen by fibroblasts, which are in turn proliferated by their stimulation.
Furthermore, fibrin binds to platelets and hyaluronic acid. Hyaluronic acid stimulates fibroblasts. accelerates hyaluronic acid production, which in turn means more water absorption and therefore increased skin volume and turgor.
i-PRF is used for both stimulation of superficial and deep dermis layers. i-PRF can be utilised as a substitute to enhance tissue regeneration, speed wound healing and enhance collagen synthesis.
Why the interest in platelets?
Platelet activation plays a key role in the body's natural healing process. The role of platelets in healing especially the coagulation cascade has been well documented.
The fact that platelets can secrete growth factors and active metabolites means that their applied use can positively influence rapid healing and tissue regeneration.
Newly released or exposed proteins and other substances stimulate tissue repair and vascular remodelling. The extracellular components (glycosaminoglycans, collagen and adhesive proteins) bind growth factors and establish a chemotactic gradient (increases chemical concentration) for cell recruitment, including a storage pool within the matrix.
Activated platelets release a plethora of growth factors which are known to regulate cell migration, vascularisation, cell proliferation, and deposition of new extracellular matrix
The Role of Growth Factors
A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.
Growth factors are important for regulating a variety of cellular processes.
The process of tissue regeneration includes a complex set of biological events controlled by the action and synergy of a cocktail of growth factors.
They often promote cell differentiation and maturation, which varies between growth factors. For example, epidermal growth factor (EGF) enhances osteogenic differentiation, while fibroblast growth factors and vascular endothelial growth factors stimulate blood vessel differentiation (angiogenesis).
What is Fibrin?
The use of growth factors and fibrin for regenerative purposes represents a new approach to aesthetic medicine.
The cellular component, a combination of multiple biological mediators that include growth factors and cytokines and a fibrin matrix or ‘scaffold’ that provides tissue construction support and acts as a net to trap platelets and growth factors.
Bacteriostatic potential is due to fibrin and not just leukocytes.
The three-dimensional cross-linked matrix serves as a scaffold for the organization of platelets, growth factors, leukocytes, cytokines, and mesenchymal stem cells during the remodelling of tissues. It massively traps the platelets and controls their release of growth factors “very slowly and continuously over a time period of more than one week”. Growth factors release rate into the target tissue is important for tissue receptors to respond over a prolonged period following treatment.
Leukocytes are Good!
Mature neutrophils have more than 700 proteins including growth factors or pro-angiogenic factors stored in their segmented nucleus and granules.
Many can be rapidly released upon activation independent of transcription and thus directly contribute to regeneration and revascularization.
The most widely studied mechanism of neutrophil contribution to tissue repair is that neutrophils become apoptotic and are cleared by macrophages. This clearance process initiates a feed-forward pro-resolution programme that is characterized by the release of the tissue-repairing cytokines transforming growth factor-β (TGFβ) and interleukin-10 (IL-10).
Thus, drugs that promote neutrophil apoptosis have a therapeutic potential to accelerate tissue repair
The addition of anticoagulants within PRP inhibit wound healing and platelet activation. A comparative study of the influence of PRP and i-PRF on osteoblast migration, proliferation and differentiation found that PRP releases most of their growth factors at very early periods compared to i-PRF which produces a more gradual and sustained release of growth factors.
Introducing the Product Line
Smart Cell tubes and centrifuge creates a blood concentrate rich in platelets, leukocytes and mesenchymal stem cells.
i-PRF Smart Cell vacutainers (12ml) for Injectable Platelet Rich Fibrin (iPRF) in aesthetics.
Unlike other tubes, the Smart Cell vacutainers come in individual sterile blister packs.
Class IIb medical device.
The tubes comply with all regulatory requirements by the EU Directive 93/42/EEC (CE 0123).
2 different kit options.
Option 1: contains 2 x 12ml tubes and will yield 4-8 ml of conditioned plasma.
Option 2: contains 4 x 12ml tubes and will yield 8-16 ml of conditioned plasma.
Note: conditioned plasma is client dependent.
Treatment Kit Contents
2 x Blood collection 21g butterfly set
2 x Luer-lock 2.5ml syringe
2 x Meso-relle needle 30gx4mm
2 x 30G 1 ½” sharp needle
2 x 30g x 13mm needle
12ml i-PRF Smart Cell vacutainers (2 or 4)
i-PRF Smart Cell Centrifuge
The i-PRF Smart Cell centrifuge is a compact low speed centrifuge capable of hosting up to 6 x 13ml test tubes.
With a small foot print of W:8.3" L:10.6" H:6.3" this centrifuge is ideal for i-PRF.
It retains the ability to be set manually and clearly displays the parameters via a digital touch panel.
Super quiet and easy to operate.
Download Smart Cell Brochure PDF
i-PRF Smart Cell tubes are CE 0123, Class IIb Medical Device according to European Commission’s MEDDEV 93/42/EEC, Classification Document Annex IX with the Rule 3 that requires clinical evaluation and biocompatibility tests that lead to the permission of clinical applications.