High Speed Vs Low Speed
The low speed centrifugation concept (LSCC) guarantees a higher concentration of platelets, growth factors and leukocytes which become trapped within the fibrin mesh resulting in a cell rich network. These essential cells are then released slowly to lead to a natural regeneration process.
Studies prove the i-PRF Smart Cell System offers a significantly higher concentration of platelets when compared to PRP following centrifugation, which highlights the superiority of Injectable Platelet Rich Fibrin and why this system is a true game changer.
The Smart Cell i-PRF system is scientifically proven to contain more platelets per mcL than traditional PRP.
i-PRF increases the remodelling of tissue through stimulating the removal of photo-damaged ECM components and inducing synthesis of new collagen by fibroblasts, which are in turn proliferated by their stimulation.
Furthermore, fibrin binds to platelets and hyaluronic acid. Hyaluronic acid stimulates fibroblasts. accelerates hyaluronic acid production, which in turn means more water absorption and therefore increased skin volume and turgor.
i-PRF is used for both stimulation of superficial and deep dermis layers. i-PRF can be utilised as a substitute to enhance tissue regeneration, speed wound healing and enhance collagen synthesis.
The addition of anticoagulants within PRP inhibit wound healing and platelet activation. A comparative study of the influence of PRP and i-PRF on osteoblast migration, proliferation and differentiation found that PRP releases most of their growth factors at very early periods compared to i-PRF which produces a more gradual and sustained release of growth factors.
Hair & Skin Rejuvenation
i-PRF is an all natural autologous treatment that stimulates hair growth where hair follicles are present but inactive.
Research shows that the higher concentration of platelets, leukocytes and presence of fibrin is superior to PRP as it can enhance the growth of hair follicles by stimulating the stem cells and other cells in the microenvironment of the hair follicle.
Fibrin functions as a matrix that traps the platelets and controls their release of growth factors “very slowly and continuously over 7-10 days. Growth factors release rate into the target tissue is important for tissue receptors to respond over a prolonged period of time following treatment.
Platelets release 7 fundamental growth factors: PDGF, FGF, VEGF, EGF, KGF, IGF, TGF-β
For patients with significant hair loss, then a combined approach is often recommended, i-PRF works well for both men and women, especially those in the early stages of hair loss.
Injectable platelet‐rich fibrin stimulates greater dermal skin fibroblast cell migration, proliferation, and collagen synthesis when compared to platelet‐rich plasma.
Skin fibroblasts migrated over 350% more with i-PRF when compared to PRP (200% increase). i-PRF also significantly induces greater cell proliferation and significantly greater ability to induce collagen matrix synthesis when compared to PRP.
i-PRF yields more than double the number of platelets which play a critical role in tissue repair and regeneration, they regulate fundamental mechanisms involved in the healing process including cellular migration, proliferation, and angiogenesis.
i-PRF is proven to be the gold standard in natural skin rejuvenation. One of the main advantages of using i-PRF as a regenerative modality in various fields of regenerative medicine is its low cost in comparison with other regenerative modalities or recombinant growth factors/hormones.
This therapy is entirely autologous without any chemical additive and offers superior tissue bio-compatibility and tissue regeneration due to the activated platelets and fibrin matrix.
Furthermore, wound healing is drastically improved with i-PRF when compared to PRP as PRP typically contains low concentrations of leukocytes. Leukocytes are the main protagonists in wound healing and the regeneration process. Their presence in autologous therapy increases the regeneration capacity.