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Plasma Filler


Smart Cell Plasma Filler is an advanced autologous treatment, utilising the patient's own plasma for the stimulation and acceleration of tissue healing and regeneration.​ It is a versatile system that allows the practitioner to formulate variable consistencies via homogenization to adapt to the characteristics of each application with excellent cell bio-compatibility and safety profile.

This novel autologous filler, is composed of the patient’s plasma, which is prepared from the patient’s own blood. It provides an immediate filler effect because of its gel-like consistency. Not only does the Plasma Filler improve volume loss, it safely boosts fibroblast expansion. 

Smart Cell Plasma Filler

A Biological Supplement


Plasma is derived when all the blood cells—red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes)—are separated from whole blood.


The cultured plasma contains water (90%), proteins (6-7%) and electrolytes such as sodium, potassium, chloride, bicarbonate, magnesium, and calcium. In addition, there are trace amounts of other substances, including amino acidsvitamins, organic acids, pigments, and enzymes.


The Plasma Filler contains very few platelets which it must be combined with i-PRF which contains a high percentage of activated platelets and growth factors as a bi-phasic treatment process. The i-PRF and Plasma must not be mixed in the same syringe.

What is Autologous


Autologous. [ ô-tŏl ′ə-gəs ] "Derived or transplanted from the same individual's body."

Autologous plasma therapy is natural treatment which taps into the regenerative potential of our bodies' platelets in order to induce tissue repair and regeneration of new tissue.

Plasma Filler utilises platelet poor plasma (PPP) for the use in tissue engineering as it offers an autologous degradable scaffold.


Although PPP has a low number of platelets (< 10 X 103/μL), it contains elevated levels of fibrinogen, a precursor of fibrin. i-PRF contains concentrated levels of activated platelets which is why i-PRF must be used in conjunction with Plasma Filler.

Fibrin binds to hyaluronic acid which stimulates human fibroblast proliferation within a collagen matrix.

Plasma Filler
Smart Cell Plasma Filler


Smart Cell Plasma Filler offers cellular rejuvenation and can be used to:

  • Add volume and smooth out creases

  • Improve fine lines and wrinkles

  • Rejuvenate peri-oral area

  • Treat décolletage

  • Plump recessed scars

  • Enhance contours such as cheeks

  • Improve laxity

  • Treat tear troughs and dark circles

  • Improve tone and texture

  • Certain body areas

A course of 2-3 treatments are recommended, results are immediately visible. Results can last up to 12 months, depending on the thickness of the filler injected and skin condition.

Prolong and improve results with regular i-PRF microneedling treatments.

Mode of Action

Suspensions of 4–5% BPP form strong, irreversible gels when heated to a minimum of 70°C. This gelation behaviour is dependent on several factors, primarily temperature, pH, heating time, and protein concentration.


While BPP begins to gel at approximately 70°C, firmer gels can be formed by increasing the temperature to 90–92°C, with even stronger gels being reported at temperatures as high as 95°C.

The Plasma Filler is then cooled prior to injection.

Plasma Filler Machine
Plasma Filler training


We welcome medical professionals and aesthetic practitioners onto the course


Pre-requisite: You must be trained in i-PRF. If you are trained in PRP, then you can do the online conversion course.

Advantages of autologous Plasma Filler:

  • Excellent safety profile

  • A natural alternative to Hyaluronic Acid dermal fillers

  • Offering clients a choice who are nervous or allergic to synthetic fillers

  • Bio-compatible 

  • Tissue regeneration

  • Non-invasive



T: 0161 885 3191 

© 2019 by i-PRF Smart Cell. All rights reserved. Part of the Cosmo Pro Ltd Group